Open Question

What is the measurement error (test-retest repeatability) of the advanced imaging biomarkers we already use to make decisions (rCBV, ADC, PET uptake)?

Evidence profile

Status: question. Rule: atlas-profile-2.0.

3 linked publications; not a count of independent studies.

Missing appraisal does not mean no evidence exists. Inspect the full profile and source relationships in the interactive Atlas.

Historical grade: MODERATE (retained from 22 September 2026; not a completed profile 2.0 assessment).

Why it matters

A biomarker's repeatability sets the floor for detectable change; most are deployed without established repeatability coefficients, so 'change' may be noise.

Conflicting evidence

Consensus acquisition recommendations exist but repeatability across the real installed base is largely unquantified.

Proposed study direction

Multi-vendor test-retest (coffee-break) studies producing repeatability coefficients and minimal-detectable-change thresholds for each biomarker.

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Gap verification

This question comes from selected literature. Confirm that the gap remains open with a current search and mentor review.

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About this page

Curated and maintained by Resonant Labs. Editorial lead: Claims are synthesized from the cited literature and graded per the Atlas methodology (about the Atlas). Page generated 2026-10-02. This is not a new clinical review date.

This is an educational research resource from Resonant Labs, not clinical advice. Atlas assessments are heuristic, not probabilities or formal GRADE ratings. Findings are summarized from the literature and may change as the field evolves.