Open Question

What is the measurement error (test-retest repeatability) of the advanced imaging biomarkers we already use to make decisions (rCBV, ADC, PET uptake)?

Evidence grade: MODERATE — Supported by moderate evidence.

Why it matters

A biomarker's repeatability sets the floor for detectable change; most are deployed without established repeatability coefficients, so 'change' may be noise.

Conflicting evidence

Consensus acquisition recommendations exist but repeatability across the real installed base is largely unquantified.

What would resolve it

Multi-vendor test-retest (coffee-break) studies producing repeatability coefficients and minimal-detectable-change thresholds for each biomarker.

Open in the interactive atlas →

About this page

Curated and maintained by Resonant Labs. Reviewed by Claims are synthesized from the cited literature and graded per the Atlas methodology (about the Atlas). Last updated 2026-07-01.

This is an educational research resource from Resonant Labs, not clinical advice. Evidence grades and controversies are summarized from the literature and may change as the field evolves.