Evidence grade: WEAK — Supported only by weak or preliminary evidence.
computed from the encoded evidence by the Atlas grading rule.
rCBV is the most reproducible advanced marker; consensus acquisition/postprocessing (leakage correction, normalization) enables standardized thresholds
Absolute thresholds vary with preload, echo, leakage-correction, and normalization ROI; multi-echo and standardization studies show persistent site dependence
Whether rCBV can serve as a decision-grade biomarker rather than a supportive one
This is an educational research resource from Resonant Labs, not clinical advice. Evidence grades and controversies are summarized from the literature and may change as the field evolves.