Status: question. Rule: atlas-profile-2.0.
3 linked publications; not a count of independent studies.
Missing appraisal does not mean no evidence exists. Inspect the full profile and source relationships in the interactive Atlas.
Historical grade: WEAK (retained from 22 September 2026; not a completed profile 2.0 assessment).
Recurrence occurs at non-enhancing infiltrative margins that current enhancement-based RANO and segmentation largely ignore; this is where patients actually fail.
RANO 2.0 de-emphasizes T2/FLAIR to reduce noise, but infiltrative progression is clinically real and undermeasured.
Develop and validate reproducible non-enhancing burden metrics vs recurrence location ground truth; inter-reader and test-retest repeatability first.
This question comes from selected literature. Confirm that the gap remains open with a current search and mentor review.
This is an educational research resource from Resonant Labs, not clinical advice. Atlas assessments are heuristic, not probabilities or formal GRADE ratings. Findings are summarized from the literature and may change as the field evolves.