Controversy

Whether removing T2/FLAIR non-enhancing assessment from enhancing-tumor evaluation in RANO 2.0 improves or degrades detection of infiltrative/non-enhancing progression

Evidence profile

Status: awaiting_review. Rule: atlas-profile-2.0.

8 linked publications; not a count of independent studies.

Missing appraisal does not mean no evidence exists. Inspect the full profile and source relationships in the interactive Atlas.

Historical grade: WEAK (retained from 22 September 2026; not a completed profile 2.0 assessment).

Position A

RANO 2.0 drops routine T2/FLAIR measurement to reduce noise and inter-reader variability; post-radiation scan as baseline reduces pseudoprogression misclassification

Position B

Non-enhancing infiltrative progression (esp. IDH-mutant, treated, anti-angiogenic) is clinically real; removing it risks under-calling true progression that enhancement misses

Clinical stakes

Directly changes trial endpoints and time-to-progression; affects when patients are switched off therapy

Open in the interactive atlas →

About this page

Curated and maintained by Resonant Labs. Editorial lead: Claims are synthesized from the cited literature and graded per the Atlas methodology (about the Atlas). Page generated 2026-10-02. This is not a new clinical review date.

This is an educational research resource from Resonant Labs, not clinical advice. Atlas assessments are heuristic, not probabilities or formal GRADE ratings. Findings are summarized from the literature and may change as the field evolves.