Evidence grade: EXPERT-CONSENSUS — Reflects expert consensus rather than definitive trial evidence.
A large fraction of imaging-outcome evidence predates CNS5; correlations may be miscalibrated to obsolete tumor classes, silently distorting current practice.
CNS5 improves biological precision but legacy imaging cohorts are rarely re-annotated and re-tested.
Re-annotate legacy imaging cohorts to CNS5 molecular entities; re-estimate imaging-biomarker associations; report which survive.
This is an educational research resource from Resonant Labs, not clinical advice. Evidence grades and controversies are summarized from the literature and may change as the field evolves.