Evidence grade: WEAK — Supported only by weak or preliminary evidence.
computed from the encoded evidence by the Atlas grading rule.
WHO CNS5 improves biological precision; imaging phenotypes can be re-mapped to molecular entities
Much legacy imaging literature is built on histologic grades now reclassified; imaging-outcome correlations need wholesale revalidation under CNS5
Entire prior imaging-biomarker evidence base may be partially miscalibrated to obsolete classes
This is an educational research resource from Resonant Labs, not clinical advice. Evidence grades and controversies are summarized from the literature and may change as the field evolves.