Controversy

How imaging should adapt to a molecularly-defined tumor taxonomy where histology-era imaging correlates may no longer hold

Evidence profile

Status: awaiting_review. Rule: atlas-profile-2.0.

5 linked publications; not a count of independent studies.

Missing appraisal does not mean no evidence exists. Inspect the full profile and source relationships in the interactive Atlas.

Historical grade: WEAK (retained from 22 September 2026; not a completed profile 2.0 assessment).

Position A

WHO CNS5 improves biological precision; imaging phenotypes can be re-mapped to molecular entities

Position B

Much legacy imaging literature is built on histologic grades now reclassified; imaging-outcome correlations need wholesale revalidation under CNS5

Clinical stakes

Entire prior imaging-biomarker evidence base may be partially miscalibrated to obsolete classes

Open in the interactive atlas →

About this page

Curated and maintained by Resonant Labs. Editorial lead: Claims are synthesized from the cited literature and graded per the Atlas methodology (about the Atlas). Page generated 2026-10-02. This is not a new clinical review date.

This is an educational research resource from Resonant Labs, not clinical advice. Atlas assessments are heuristic, not probabilities or formal GRADE ratings. Findings are summarized from the literature and may change as the field evolves.