Evidence grade: UNRESOLVED-CONTROVERSY — Genuinely unsettled — the evidence conflicts.
This is the single most common unresolved daily decision in neuro-oncology; current practice defaults to watchful waiting, delaying effective therapy or prolonging toxic ineffective therapy.
Cohort-level separation exists (perfusion, PET) but thresholds do not transfer across sites; RANO 2.0 still relies on confirmation scans.
Prospective multi-vendor cohort with biopsy/long-follow-up ground truth, pre-registered thresholds, calibration + decision-curve analysis; amino-acid PET arm where available.
This is an educational research resource from Resonant Labs, not clinical advice. Evidence grades and controversies are summarized from the literature and may change as the field evolves.