Controversy

There is no validated imaging biomarker that reliably distinguishes pseudoprogression from true early progression at the individual-patient level

Evidence profile

Status: awaiting_review. Rule: atlas-profile-2.0.

24 linked publications; not a count of independent studies.

Missing appraisal does not mean no evidence exists. Inspect the full profile and source relationships in the interactive Atlas.

Historical grade: WEAK (retained from 22 September 2026; not a completed profile 2.0 assessment).

Position A

Advanced imaging (DSC rCBV, DCE, diffusion, amino-acid PET) separates the two on average in cohorts

Position B

At the single-patient level thresholds are non-transferable across scanners/protocols; confirmation-scan waiting remains the de-facto standard

Clinical stakes

Premature therapy discontinuation vs. continuing ineffective toxic therapy; a core daily neuro-oncology decision

Open in the interactive atlas →

About this page

Curated and maintained by Resonant Labs. Editorial lead: Claims are synthesized from the cited literature and graded per the Atlas methodology (about the Atlas). Page generated 2026-10-02. This is not a new clinical review date.

This is an educational research resource from Resonant Labs, not clinical advice. Atlas assessments are heuristic, not probabilities or formal GRADE ratings. Findings are summarized from the literature and may change as the field evolves.