Controversy

There is no validated imaging biomarker that reliably distinguishes pseudoprogression from true early progression at the individual-patient level

Evidence grade: WEAK — Supported only by weak or preliminary evidence.

computed from the encoded evidence by the Atlas grading rule.

Position A

Advanced imaging (DSC rCBV, DCE, diffusion, amino-acid PET) separates the two on average in cohorts

Position B

At the single-patient level thresholds are non-transferable across scanners/protocols; confirmation-scan waiting remains the de-facto standard

Clinical stakes

Premature therapy discontinuation vs. continuing ineffective toxic therapy; a core daily neuro-oncology decision

Open in the interactive atlas →

About this page

Curated and maintained by Resonant Labs. Reviewed by Claims are synthesized from the cited literature and graded per the Atlas methodology (about the Atlas). Last updated 2026-07-01.

This is an educational research resource from Resonant Labs, not clinical advice. Evidence grades and controversies are summarized from the literature and may change as the field evolves.