Controversy

Whether hand-crafted radiomic signatures are stable enough to be biomarkers, or are dominated by acquisition/segmentation/software variation

Evidence profile

Status: awaiting_review. Rule: atlas-profile-2.0.

10 linked publications; not a count of independent studies.

Missing appraisal does not mean no evidence exists. Inspect the full profile and source relationships in the interactive Atlas.

Historical grade: WEAK (retained from 22 September 2026; not a completed profile 2.0 assessment).

Position A

IBSI standardization and ComBat harmonization make radiomic features reproducible and poolable

Position B

Features remain sensitive to voxel resampling, segmentation, scanner, and software; harmonization can remove real biological signal along with batch effect

Clinical stakes

Reproducibility crisis undermines translation of the entire hand-crafted radiomics enterprise

Open in the interactive atlas →

About this page

Curated and maintained by Resonant Labs. Editorial lead: Claims are synthesized from the cited literature and graded per the Atlas methodology (about the Atlas). Page generated 2026-10-02. This is not a new clinical review date.

This is an educational research resource from Resonant Labs, not clinical advice. Atlas assessments are heuristic, not probabilities or formal GRADE ratings. Findings are summarized from the literature and may change as the field evolves.