Evidence grade: MODERATE — Supported by moderate evidence.
Segmentation is near-solved technically, but whether volumetrics actually alter response classification and outcomes is unproven; effort has outpaced evidence of value.
BraTS-driven segmentation is robust, but volumetric RANO is not standard and marginal Dice gains lack demonstrated clinical translation.
Re-analyze completed trials with automated volumetrics vs bidimensional RANO; test whether response category and hazard estimates change.
This is an educational research resource from Resonant Labs, not clinical advice. Evidence grades and controversies are summarized from the literature and may change as the field evolves.