Evidence grade: WEAK — Supported only by weak or preliminary evidence.
computed from the encoded evidence by the Atlas grading rule.
Radiomic/multimodal ML classifiers report high AUCs for HPV status and treatment response
Models are overwhelmingly internal-validation-only, single-center, and not externally validated; imaging cannot replace p16/HPV testing
Premature imaging-based HPV assignment could misdirect de-escalation trials; the endpoint (HPV) already has a reference test.
This is an educational research resource from Resonant Labs, not clinical advice. Evidence grades and controversies are summarized from the literature and may change as the field evolves.