Controversy

Can imaging (CT/MRI) reliably diagnose extranodal extension (ENE), now an AJCC8 staging factor?

Evidence profile

Status: awaiting_review. Rule: atlas-profile-2.0.

6 linked publications; not a count of independent studies.

Missing appraisal does not mean no evidence exists. Inspect the full profile and source relationships in the interactive Atlas.

Historical grade: WEAK (retained from 22 September 2026; not a completed profile 2.0 assessment).

Position A

Defined CT/MRI criteria and, increasingly, AI models detect ENE with clinically useful accuracy and prognostic value

Position B

Diagnostic performance is moderate with limited reproducibility; consensus criteria are only now emerging and AI models are largely internally validated

Clinical stakes

Imaging-called ENE upstages disease and shifts patients toward chemoradiation/surgery; false positives overtreat.

Open in the interactive atlas →

About this page

Curated and maintained by Resonant Labs. Editorial lead: Claims are synthesized from the cited literature and graded per the Atlas methodology (about the Atlas). Page generated 2026-10-02. This is not a new clinical review date.

This is an educational research resource from Resonant Labs, not clinical advice. Atlas assessments are heuristic, not probabilities or formal GRADE ratings. Findings are summarized from the literature and may change as the field evolves.