Evidence grade: WEAK — Supported only by weak or preliminary evidence.
computed from the encoded evidence by the Atlas grading rule.
IDH status has real radiologic correlates (T2-FLAIR mismatch, frontal location, less enhancement); DL models reach high internal AUC
T2-FLAIR mismatch is highly specific but low-sensitivity; whole-model DL claims rarely externally validated on scanner-diverse cohorts
WHO CNS5 requires molecular status; imaging surrogates could triage but not replace tissue
This is an educational research resource from Resonant Labs, not clinical advice. Evidence grades and controversies are summarized from the literature and may change as the field evolves.