Controversy

How much of reported IDH/glioma-subtype imaging prediction reflects genuine biology vs confounded/leaky pipelines

Evidence profile

Status: awaiting_review. Rule: atlas-profile-2.0.

20 linked publications; not a count of independent studies.

Missing appraisal does not mean no evidence exists. Inspect the full profile and source relationships in the interactive Atlas.

Historical grade: WEAK (retained from 22 September 2026; not a completed profile 2.0 assessment).

Position A

IDH status has real radiologic correlates (T2-FLAIR mismatch, frontal location, less enhancement); DL models reach high internal AUC

Position B

T2-FLAIR mismatch is highly specific but low-sensitivity; whole-model DL claims rarely externally validated on scanner-diverse cohorts

Clinical stakes

WHO CNS5 requires molecular status; imaging surrogates could triage but not replace tissue

Open in the interactive atlas →

About this page

Curated and maintained by Resonant Labs. Editorial lead: Claims are synthesized from the cited literature and graded per the Atlas methodology (about the Atlas). Page generated 2026-10-02. This is not a new clinical review date.

This is an educational research resource from Resonant Labs, not clinical advice. Atlas assessments are heuristic, not probabilities or formal GRADE ratings. Findings are summarized from the literature and may change as the field evolves.