Evidence grade: WEAK — Supported only by weak or preliminary evidence.
computed from the encoded evidence by the Atlas grading rule.
Multiple ML/DL models report AUCs 0.7-0.9 for MGMT prediction on multiparametric MRI
Well-designed studies conclude MRI cannot reliably predict MGMT; BraTS-MGMT-style tasks show near-chance external performance; positive results attributed to leakage/overfitting
MGMT governs temozolomide benefit; a false imaging surrogate could misdirect therapy or trial stratification
This is an educational research resource from Resonant Labs, not clinical advice. Evidence grades and controversies are summarized from the literature and may change as the field evolves.